SidaGhanaV1, Main, Exploration, bibRecord, 000A42

CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population

Identifieur interne : 000A42 ( Main/Exploration ); précédent : 000A41; suivant : 000A43

CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population

Auteurs : Thorsten Thye [Allemagne] ; Genevieve Scarisbrick [Ghana] ; Edmund N. L. Browne [Ghana] ; Margaret Amanua Chinbuah [Ghana] ; John Gyapong [Ghana] ; Ivy Osei [Ghana] ; Ellis Owusu-Dabo [Ghana] ; Stefan Niemann [Allemagne] ; Sabine Rüsch-Gerdes [Allemagne] ; Christian G. Meyer [Allemagne] ; Rolf D. Horstmann [Allemagne]

Source :

PLoS ONE [ 1932-6203 ] ; 2009.

RBID : PMC:2707621

Descripteurs français

KwdFr :
- Amorces ADN, Antigène CTLA-4, Antigènes CD (immunologie), Ghana, Génotype, Haplotypes, Humains, Maladies auto-immunes (génétique), Maladies auto-immunes (immunologie), Polymorphisme de nucléotide simple, Séquence nucléotidique, Tuberculose pulmonaire (génétique), Tuberculose pulmonaire (immunologie), Études cas-témoins.
MESH :
- génétique : Maladies auto-immunes, Tuberculose pulmonaire.
- immunologie : Antigènes CD, Maladies auto-immunes, Tuberculose pulmonaire.
- Amorces ADN, Antigène CTLA-4, Ghana, Génotype, Haplotypes, Humains, Polymorphisme de nucléotide simple, Séquence nucléotidique, Études cas-témoins.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Antigens, CD (immunology), Autoimmune Diseases (genetics), Autoimmune Diseases (immunology), Base Sequence, CTLA-4 Antigen, Case-Control Studies, DNA Primers, Genotype, Ghana, Haplotypes, Humans, Polymorphism, Single Nucleotide, Tuberculosis, Pulmonary (genetics), Tuberculosis, Pulmonary (immunology).
MESH :
- chemical , immunology : Antigens, CD.
- geographic : Ghana.
- genetics : Autoimmune Diseases, Tuberculosis, Pulmonary.
- immunology : Autoimmune Diseases, Tuberculosis, Pulmonary.
- Base Sequence, CTLA-4 Antigen, Case-Control Studies, DNA Primers, Genotype, Haplotypes, Humans, Polymorphism, Single Nucleotide.

Abstract

The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory activity. In Ghana, West Africa, we compared the frequencies of CTLA4 +6230 A/G and 6 haplotype-tagging SNPs in 2010 smear-positive, HIV-negative patients with pulmonary tuberculosis (TB) and 2346 controls matched for age, gender and ethnicity. We found no difference in allele frequencies between cases and controls. However, +6230A and a distinct CTLA4 haplotype and a diplotype comprising the +6230A allele were significantly less frequent among cases with large opacities in chest radiographs compared to those with small ones (P_{corrected [cor]} = 0.002, P_cor = 0.00045, P = 0.0005, respectively). This finding suggests that an increased T-cell activity associated with the CTLA4 +6230G allele contributes to pathology rather than to protection in pulmonary TB.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707621

DOI: 10.1371/journal.pone.0006307
PubMed: 19609446
PubMed Central: 2707621

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>CTLA4</italic>
 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population</title>
<author><name sortKey="Thye, Thorsten" sort="Thye, Thorsten" uniqKey="Thye T" first="Thorsten" last="Thye">Thorsten Thye</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck</wicri:regionArea>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scarisbrick, Genevieve" sort="Scarisbrick, Genevieve" uniqKey="Scarisbrick G" first="Genevieve" last="Scarisbrick">Genevieve Scarisbrick</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Radiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Radiology, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Browne, Edmund N L" sort="Browne, Edmund N L" uniqKey="Browne E" first="Edmund N. L." last="Browne">Edmund N. L. Browne</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinbuah, Margaret Amanua" sort="Chinbuah, Margaret Amanua" uniqKey="Chinbuah M" first="Margaret Amanua" last="Chinbuah">Margaret Amanua Chinbuah</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Health Research Unit, Ghana Health Service, Ministry of Health, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Health Research Unit, Ghana Health Service, Ministry of Health, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gyapong, John" sort="Gyapong, John" uniqKey="Gyapong J" first="John" last="Gyapong">John Gyapong</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Health Research Unit, Ghana Health Service, Ministry of Health, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Health Research Unit, Ghana Health Service, Ministry of Health, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osei, Ivy" sort="Osei, Ivy" uniqKey="Osei I" first="Ivy" last="Osei">Ivy Osei</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Health Research Unit, Ghana Health Service, Ministry of Health, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Health Research Unit, Ghana Health Service, Ministry of Health, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Owusu Dabo, Ellis" sort="Owusu Dabo, Ellis" uniqKey="Owusu Dabo E" first="Ellis" last="Owusu-Dabo">Ellis Owusu-Dabo</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niemann, Stefan" sort="Niemann, Stefan" uniqKey="Niemann S" first="Stefan" last="Niemann">Stefan Niemann</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Reference Center for Mycobacteria, Research Center Borstel, Borstel</wicri:regionArea>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rusch Gerdes, Sabine" sort="Rusch Gerdes, Sabine" uniqKey="Rusch Gerdes S" first="Sabine" last="Rüsch-Gerdes">Sabine Rüsch-Gerdes</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Reference Center for Mycobacteria, Research Center Borstel, Borstel</wicri:regionArea>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyer, Christian G" sort="Meyer, Christian G" uniqKey="Meyer C" first="Christian G." last="Meyer">Christian G. Meyer</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Horstmann, Rolf D" sort="Horstmann, Rolf D" uniqKey="Horstmann R" first="Rolf D." last="Horstmann">Rolf D. Horstmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19609446</idno>
<idno type="pmc">2707621</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707621</idno>
<idno type="RBID">PMC:2707621</idno>
<idno type="doi">10.1371/journal.pone.0006307</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000490</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000490</idno>
<idno type="wicri:Area/Pmc/Curation">000489</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000489</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000454</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000454</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000668</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000668</idno>
<idno type="wicri:Area/PubMed/Curation">000668</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000668</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000668</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000668</idno>
<idno type="wicri:Area/Ncbi/Merge">000337</idno>
<idno type="wicri:Area/Ncbi/Curation">000337</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000337</idno>
<idno type="wicri:Area/Main/Merge">000A55</idno>
<idno type="wicri:Area/Main/Curation">000A42</idno>
<idno type="wicri:Area/Main/Exploration">000A42</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>CTLA4</italic>
 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population</title>
<author><name sortKey="Thye, Thorsten" sort="Thye, Thorsten" uniqKey="Thye T" first="Thorsten" last="Thye">Thorsten Thye</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck</wicri:regionArea>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scarisbrick, Genevieve" sort="Scarisbrick, Genevieve" uniqKey="Scarisbrick G" first="Genevieve" last="Scarisbrick">Genevieve Scarisbrick</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Radiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Radiology, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Browne, Edmund N L" sort="Browne, Edmund N L" uniqKey="Browne E" first="Edmund N. L." last="Browne">Edmund N. L. Browne</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinbuah, Margaret Amanua" sort="Chinbuah, Margaret Amanua" uniqKey="Chinbuah M" first="Margaret Amanua" last="Chinbuah">Margaret Amanua Chinbuah</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Health Research Unit, Ghana Health Service, Ministry of Health, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Health Research Unit, Ghana Health Service, Ministry of Health, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gyapong, John" sort="Gyapong, John" uniqKey="Gyapong J" first="John" last="Gyapong">John Gyapong</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Health Research Unit, Ghana Health Service, Ministry of Health, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Health Research Unit, Ghana Health Service, Ministry of Health, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osei, Ivy" sort="Osei, Ivy" uniqKey="Osei I" first="Ivy" last="Osei">Ivy Osei</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Health Research Unit, Ghana Health Service, Ministry of Health, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Health Research Unit, Ghana Health Service, Ministry of Health, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Owusu Dabo, Ellis" sort="Owusu Dabo, Ellis" uniqKey="Owusu Dabo E" first="Ellis" last="Owusu-Dabo">Ellis Owusu-Dabo</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Community Health, College of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niemann, Stefan" sort="Niemann, Stefan" uniqKey="Niemann S" first="Stefan" last="Niemann">Stefan Niemann</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Reference Center for Mycobacteria, Research Center Borstel, Borstel</wicri:regionArea>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rusch Gerdes, Sabine" sort="Rusch Gerdes, Sabine" uniqKey="Rusch Gerdes S" first="Sabine" last="Rüsch-Gerdes">Sabine Rüsch-Gerdes</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Reference Center for Mycobacteria, Research Center Borstel, Borstel</wicri:regionArea>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
<wicri:noRegion>Borstel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyer, Christian G" sort="Meyer, Christian G" uniqKey="Meyer C" first="Christian G." last="Meyer">Christian G. Meyer</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Horstmann, Rolf D" sort="Horstmann, Rolf D" uniqKey="Horstmann R" first="Rolf D." last="Horstmann">Rolf D. Horstmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, CD (immunology)</term>
<term>Autoimmune Diseases (genetics)</term>
<term>Autoimmune Diseases (immunology)</term>
<term>Base Sequence</term>
<term>CTLA-4 Antigen</term>
<term>Case-Control Studies</term>
<term>DNA Primers</term>
<term>Genotype</term>
<term>Ghana</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Tuberculosis, Pulmonary (genetics)</term>
<term>Tuberculosis, Pulmonary (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Amorces ADN</term>
<term>Antigène CTLA-4</term>
<term>Antigènes CD (immunologie)</term>
<term>Ghana</term>
<term>Génotype</term>
<term>Haplotypes</term>
<term>Humains</term>
<term>Maladies auto-immunes (génétique)</term>
<term>Maladies auto-immunes (immunologie)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Séquence nucléotidique</term>
<term>Tuberculose pulmonaire (génétique)</term>
<term>Tuberculose pulmonaire (immunologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autoimmune Diseases</term>
<term>Tuberculosis, Pulmonary</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maladies auto-immunes</term>
<term>Tuberculose pulmonaire</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term>
<term>Maladies auto-immunes</term>
<term>Tuberculose pulmonaire</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmune Diseases</term>
<term>Tuberculosis, Pulmonary</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>CTLA-4 Antigen</term>
<term>Case-Control Studies</term>
<term>DNA Primers</term>
<term>Genotype</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Amorces ADN</term>
<term>Antigène CTLA-4</term>
<term>Ghana</term>
<term>Génotype</term>
<term>Haplotypes</term>
<term>Humains</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Séquence nucléotidique</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (<italic>CTLA4</italic>
), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory activity. In Ghana, West Africa, we compared the frequencies of <italic>CTLA4</italic>
 +6230 A/G and 6 haplotype-tagging SNPs in 2010 smear-positive, HIV-negative patients with pulmonary tuberculosis (TB) and 2346 controls matched for age, gender and ethnicity. We found no difference in allele frequencies between cases and controls. However, +6230A and a distinct <italic>CTLA4</italic>
 haplotype and a diplotype comprising the +6230A allele were significantly less frequent among cases with large opacities in chest radiographs compared to those with small ones (P<sub>corrected [cor]</sub>
 = 0.002, P<sub>cor</sub>
 = 0.00045, P = 0.0005, respectively). This finding suggests that an increased T-cell activity associated with the <italic>CTLA4</italic>
 +6230G allele contributes to pathology rather than to protection in pulmonary TB.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Teft, Wa" uniqKey="Teft W">WA Teft</name>
</author>
<author><name sortKey="Kirchhof, Mg" uniqKey="Kirchhof M">MG Kirchhof</name>
</author>
<author><name sortKey="Madrenas, J" uniqKey="Madrenas J">J Madrenas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Km" uniqKey="Lee K">KM Lee</name>
</author>
<author><name sortKey="Chuang, E" uniqKey="Chuang E">E Chuang</name>
</author>
<author><name sortKey="Griffin, M" uniqKey="Griffin M">M Griffin</name>
</author>
<author><name sortKey="Khattri, R" uniqKey="Khattri R">R Khattri</name>
</author>
<author><name sortKey="Hong, Dk" uniqKey="Hong D">DK Hong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sansom, Dm" uniqKey="Sansom D">DM Sansom</name>
</author>
<author><name sortKey="Walker, Ls" uniqKey="Walker L">LS Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Darlington, Pj" uniqKey="Darlington P">PJ Darlington</name>
</author>
<author><name sortKey="Baroja, Ml" uniqKey="Baroja M">ML Baroja</name>
</author>
<author><name sortKey="Chau, Ta" uniqKey="Chau T">TA Chau</name>
</author>
<author><name sortKey="Siu, E" uniqKey="Siu E">E Siu</name>
</author>
<author><name sortKey="Ling, V" uniqKey="Ling V">V Ling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schneider, H" uniqKey="Schneider H">H Schneider</name>
</author>
<author><name sortKey="Valk, E" uniqKey="Valk E">E Valk</name>
</author>
<author><name sortKey="Da Rocha Dias, S" uniqKey="Da Rocha Dias S">S da Rocha Dias</name>
</author>
<author><name sortKey="Wei, B" uniqKey="Wei B">B Wei</name>
</author>
<author><name sortKey="Rudd, Ce" uniqKey="Rudd C">CE Rudd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schneider, H" uniqKey="Schneider H">H Schneider</name>
</author>
<author><name sortKey="Downey, J" uniqKey="Downey J">J Downey</name>
</author>
<author><name sortKey="Smith, A" uniqKey="Smith A">A Smith</name>
</author>
<author><name sortKey="Zinselmeyer, Bh" uniqKey="Zinselmeyer B">BH Zinselmeyer</name>
</author>
<author><name sortKey="Rush, C" uniqKey="Rush C">C Rush</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grohmann, U" uniqKey="Grohmann U">U Grohmann</name>
</author>
<author><name sortKey="Orabona, C" uniqKey="Orabona C">C Orabona</name>
</author>
<author><name sortKey="Fallarino, F" uniqKey="Fallarino F">F Fallarino</name>
</author>
<author><name sortKey="Vacca, C" uniqKey="Vacca C">C Vacca</name>
</author>
<author><name sortKey="Calcinaro, F" uniqKey="Calcinaro F">F Calcinaro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bour Jordan, H" uniqKey="Bour Jordan H">H Bour-Jordan</name>
</author>
<author><name sortKey="Grogan, Jl" uniqKey="Grogan J">JL Grogan</name>
</author>
<author><name sortKey="Tang, Q" uniqKey="Tang Q">Q Tang</name>
</author>
<author><name sortKey="Auger, Ja" uniqKey="Auger J">JA Auger</name>
</author>
<author><name sortKey="Locksley, Rm" uniqKey="Locksley R">RM Locksley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nasta, F" uniqKey="Nasta F">F Nasta</name>
</author>
<author><name sortKey="Ubaldi, V" uniqKey="Ubaldi V">V Ubaldi</name>
</author>
<author><name sortKey="Pace, L" uniqKey="Pace L">L Pace</name>
</author>
<author><name sortKey="Doria, G" uniqKey="Doria G">G Doria</name>
</author>
<author><name sortKey="Pioli, C" uniqKey="Pioli C">C Pioli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ueda, H" uniqKey="Ueda H">H Ueda</name>
</author>
<author><name sortKey="Howson, Jm" uniqKey="Howson J">JM Howson</name>
</author>
<author><name sortKey="Esposito, L" uniqKey="Esposito L">L Esposito</name>
</author>
<author><name sortKey="Heward, J" uniqKey="Heward J">J Heward</name>
</author>
<author><name sortKey="Snook, H" uniqKey="Snook H">H Snook</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maier, Lm" uniqKey="Maier L">LM Maier</name>
</author>
<author><name sortKey="Anderson, De" uniqKey="Anderson D">DE Anderson</name>
</author>
<author><name sortKey="De Jager, Pl" uniqKey="De Jager P">PL De Jager</name>
</author>
<author><name sortKey="Wicker, Ls" uniqKey="Wicker L">LS Wicker</name>
</author>
<author><name sortKey="Hafler, Da" uniqKey="Hafler D">DA Hafler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flynn, Jl" uniqKey="Flynn J">JL Flynn</name>
</author>
<author><name sortKey="Chan, J" uniqKey="Chan J">J Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramirez Soriano, A" uniqKey="Ramirez Soriano A">A Ramírez-Soriano</name>
</author>
<author><name sortKey="Lao, O" uniqKey="Lao O">O Lao</name>
</author>
<author><name sortKey="Soldevila, M" uniqKey="Soldevila M">M Soldevila</name>
</author>
<author><name sortKey="Calafell, F" uniqKey="Calafell F">F Calafell</name>
</author>
<author><name sortKey="Bertranpetit, J" uniqKey="Bertranpetit J">J Bertranpetit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thye, T" uniqKey="Thye T">T Thye</name>
</author>
<author><name sortKey="Browne, En" uniqKey="Browne E">EN Browne</name>
</author>
<author><name sortKey="Chinbuah, Ma" uniqKey="Chinbuah M">MA Chinbuah</name>
</author>
<author><name sortKey="Gyapong, J" uniqKey="Gyapong J">J Gyapong</name>
</author>
<author><name sortKey="Osei, I" uniqKey="Osei I">I Osei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kirman, J" uniqKey="Kirman J">J Kirman</name>
</author>
<author><name sortKey="Mccoy, K" uniqKey="Mccoy K">K McCoy</name>
</author>
<author><name sortKey="Hook, S" uniqKey="Hook S">S Hook</name>
</author>
<author><name sortKey="Prout, M" uniqKey="Prout M">M Prout</name>
</author>
<author><name sortKey="Delahunt, B" uniqKey="Delahunt B">B Delahunt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quinn, Km" uniqKey="Quinn K">KM Quinn</name>
</author>
<author><name sortKey="Mchugh, Rs" uniqKey="Mchugh R">RS McHugh</name>
</author>
<author><name sortKey="Rich, Fj" uniqKey="Rich F">FJ Rich</name>
</author>
<author><name sortKey="Goldsack, Lm" uniqKey="Goldsack L">LM Goldsack</name>
</author>
<author><name sortKey="De Lisle, Gw" uniqKey="De Lisle G">GW de Lisle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name>
</author>
<author><name sortKey="Lee, Ks" uniqKey="Lee K">KS Lee</name>
</author>
<author><name sortKey="Jung, Kj" uniqKey="Jung K">KJ Jung</name>
</author>
<author><name sortKey="Han, J" uniqKey="Han J">J Han</name>
</author>
<author><name sortKey="Kwon, Oj" uniqKey="Kwon O">OJ Kwon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lawn, Sd" uniqKey="Lawn S">SD Lawn</name>
</author>
<author><name sortKey="Bekker, Lg" uniqKey="Bekker L">LG Bekker</name>
</author>
<author><name sortKey="Miller, Rf" uniqKey="Miller R">RF Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thio, Cl" uniqKey="Thio C">CL Thio</name>
</author>
<author><name sortKey="Mosbruger, Tl" uniqKey="Mosbruger T">TL Mosbruger</name>
</author>
<author><name sortKey="Kaslow, Ra" uniqKey="Kaslow R">RA Kaslow</name>
</author>
<author><name sortKey="Karp, Cl" uniqKey="Karp C">CL Karp</name>
</author>
<author><name sortKey="Strathdee, Sa" uniqKey="Strathdee S">SA Strathdee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kavvoura, Fk" uniqKey="Kavvoura F">FK Kavvoura</name>
</author>
<author><name sortKey="Akamizu, T" uniqKey="Akamizu T">T Akamizu</name>
</author>
<author><name sortKey="Awata, T" uniqKey="Awata T">T Awata</name>
</author>
<author><name sortKey="Ban, Y" uniqKey="Ban Y">Y Ban</name>
</author>
<author><name sortKey="Chistiakov, Da" uniqKey="Chistiakov D">DA Chistiakov</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Ghana</li>
</country>
<region><li>Hambourg</li>
<li>Région du Grand Accra</li>
</region>
<settlement><li>Accra</li>
<li>Hambourg</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Thye, Thorsten" sort="Thye, Thorsten" uniqKey="Thye T" first="Thorsten" last="Thye">Thorsten Thye</name>
</region>
<name sortKey="Horstmann, Rolf D" sort="Horstmann, Rolf D" uniqKey="Horstmann R" first="Rolf D." last="Horstmann">Rolf D. Horstmann</name>
<name sortKey="Meyer, Christian G" sort="Meyer, Christian G" uniqKey="Meyer C" first="Christian G." last="Meyer">Christian G. Meyer</name>
<name sortKey="Niemann, Stefan" sort="Niemann, Stefan" uniqKey="Niemann S" first="Stefan" last="Niemann">Stefan Niemann</name>
<name sortKey="Rusch Gerdes, Sabine" sort="Rusch Gerdes, Sabine" uniqKey="Rusch Gerdes S" first="Sabine" last="Rüsch-Gerdes">Sabine Rüsch-Gerdes</name>
<name sortKey="Thye, Thorsten" sort="Thye, Thorsten" uniqKey="Thye T" first="Thorsten" last="Thye">Thorsten Thye</name>
</country>
<country name="Ghana"><noRegion><name sortKey="Scarisbrick, Genevieve" sort="Scarisbrick, Genevieve" uniqKey="Scarisbrick G" first="Genevieve" last="Scarisbrick">Genevieve Scarisbrick</name>
</noRegion>
<name sortKey="Browne, Edmund N L" sort="Browne, Edmund N L" uniqKey="Browne E" first="Edmund N. L." last="Browne">Edmund N. L. Browne</name>
<name sortKey="Chinbuah, Margaret Amanua" sort="Chinbuah, Margaret Amanua" uniqKey="Chinbuah M" first="Margaret Amanua" last="Chinbuah">Margaret Amanua Chinbuah</name>
<name sortKey="Gyapong, John" sort="Gyapong, John" uniqKey="Gyapong J" first="John" last="Gyapong">John Gyapong</name>
<name sortKey="Osei, Ivy" sort="Osei, Ivy" uniqKey="Osei I" first="Ivy" last="Osei">Ivy Osei</name>
<name sortKey="Owusu Dabo, Ellis" sort="Owusu Dabo, Ellis" uniqKey="Owusu Dabo E" first="Ellis" last="Owusu-Dabo">Ellis Owusu-Dabo</name>
<name sortKey="Owusu Dabo, Ellis" sort="Owusu Dabo, Ellis" uniqKey="Owusu Dabo E" first="Ellis" last="Owusu-Dabo">Ellis Owusu-Dabo</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A42 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A42 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaGhanaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2707621
   |texte=   CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19609446" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SidaGhanaV1

This area was generated with Dilib version V0.6.31.
Data generation: Tue Nov 7 18:07:38 2017. Site generation: Tue Mar 5 15:01:57 2024

Le SIDA au Ghana (serveur d'exploration)

CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population

CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.